Article
Brefeldin A sensitivity and resistance in Schizosaccharomyces pombe. Isolation of multiple genes conferring resistance.
The Journal of biological chemistry - 30 Sept 1994
Turi T G, Webster P, Rose J K
Abstract excerpt
The fungal metabolite brefeldin A (BFA) causes the inhibition of protein secretion and the disruption of the structure and function of the Golgi complex in mammalian cells. Here we show that BFA has identical effects in the fission yeast Schizosaccharomyces pombe which normally contains a Golgi c...
Topics
- Amino Acid Sequence
- Antifungal Agents
- Brefeldin A
- Cyclopentanes
- Drug Resistance, Microbial
- Fungal Proteins
- Golgi Apparatus
- Karyopherins
- Molecular Sequence Data
- Mutation
- Pancreatitis-Associated Proteins
- Phenotype
- Plasmids
- Receptors, Cytoplasmic and Nuclear
- Saccharomyces cerevisiae
- Schizosaccharomyces
- Sequence Homology, Amino Acid
- Exportin 1 Protein