Article
Influence of antigenic experience on BJ gene segment usage in human CD4+ T cells.
International immunology - 1 Dec 1997
Walser-Kuntz D R, Weyand C M, Goronzy J J
Abstract excerpt
HLA molecules influence the selection of naive CD4+ T cells as demonstrated by HLA-DR-dependent differences in BV8-BJ frequencies. The repertoire of mature peripheral T cells utilized in antigen responses is shaped by additional factors such as antigens encountered in the environment. To identify mechanisms underlying the formation of the memory repertoire, differences in the BV8-BJ repertoire of CD45RO- and...
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