Article
Human TCR as antigen: homologies and potentially cross-reactive HLA-DR2-restricted epitopes within the AV and BV CDR2 loops.
Critical reviews in immunology - 1 Jan 2000
Vandenbark A A, Culbertson N, Finn T, Barnes D, Buenafe A, Burrows G G, Law S, Chou Y K, Offner H
Abstract excerpt
The major function of the T-cell receptor is to confer antigen specificity to T cells. However, nascent TCR proteins that are not assembled into functional heterodimers may be processed and displayed with self MHC molecules on the T-cell surface, and are thought to be the genesis of autoregulatory T cells that can limit inflammatory responses through T-T network interactions. In previous work, we and others have...
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