Article
Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells.
Immunogenetics - 1 Jan 1995
Quiròs Roldan E, Sottini A, Bettinardi A, Albertini A, Imberti L, Primi D
Abstract excerpt
The aim of this work was to assess whether each T-cell receptor (TCR) BV segment generates a random pattern of junctional diversity or if, alternatively, biased patterns of V-D-J rearrangements limit the number of available TCR specificities. Detailed molecular analysis of T-cell receptors expressed by lymphocytes was obtained by generating a large number of junctional regions sequences from TCRBV3, TCRBV4,...
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