Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells.

doi:10.1007/BF00182318

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Article

Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells.

Immunogenetics - 1 Jan 1995

Quiròs Roldan E, Sottini A, Bettinardi A, Albertini A, Imberti L, Primi D

Abstract excerpt

The aim of this work was to assess whether each T-cell receptor (TCR) BV segment generates a random pattern of junctional diversity or if, alternatively, biased patterns of V-D-J rearrangements limit the number of available TCR specificities. Detailed molecular analysis of T-cell receptors expres...

Topics

Base Sequence
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genetic Variation
Humans
Molecular Sequence Data
Receptors, Antigen, T-Cell, alpha-beta
Recombination, Genetic
Sequence Analysis, DNA
Sequence Deletion
T-Lymphocytes

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