Article
Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.
PloS one - 1 Jan 2015
Kim Joseph Y, Balamurugan Arumugam, Azari Kodi, Hofmann Christian, Ng Hwee L, Reed Elaine F, McDiarmid Suzanne, Yang Otto O
Abstract excerpt
Immune prophylaxis and treatment of transplanted tissue rejection act indiscriminately, risking serious infections and malignancies. Although animal data suggest that cellular immune responses causing rejection may be rather narrow and predictable based on genetic background, there are only limited data regarding the clonal breadth of anti-donor responses in humans after allogeneic organ transplantation. We...
Topics
- Adult
- Amino Acid Sequence
- Animals
- CD8-Positive T-Lymphocytes
- Female
- Genes, T-Cell Receptor
- Genetic Variation
- Graft Rejection
- Hand Transplantation
- Humans
- Models, Immunological
- Molecular Sequence Data
- Sequence Homology, Amino Acid