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Article

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.

1 Nov 1993

Abstract excerpt

Structural models for the TCR alpha/beta predict that the CDR1, CDR2, and CDR3 loops of both the alpha- and beta-chains contribute to specific interactions with the Ag/MHC complex. The CDR3 loops are constructed by joining events involving the V-(D)-J segments, and thus may vary in both sequence and length. We have developed a polymerase chain reaction assay to assess the length variation of the CDR3 loop in TCR...

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Identifiers

PMID: 8228260
DOI: 10.4049/jimmunol.151.10.5762

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