Article
T-cell expansions with conserved T-cell receptor beta chain motifs in the peripheral blood of HLA-DRB1*0401 positive patients with necrotizing vasculitis.
Blood - 15 Nov 1998
Grunewald J, Halapi E, Wahlström J, Giscombe R, Nityanand S, Sanjeevi C, Lefvert A K
Abstract excerpt
T lymphocytes are implicated in the pathogenesis of systemic vasculitis such as Wegener's granulomatosis (WG) and polyarteritis nodosa (PAN). In the present study, we have characterized in detail the T-cell receptor (TCR) of peripheral blood T cells from eight vasculitis patients of known HLA cla...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Sequence
- Autoantigens
- Autoimmune Diseases
- CD4-Positive T-Lymphocytes
- Clone Cells
- Female
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Genotype
- Granulomatosis with Polyangiitis
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Lymphocyte Activation
- Lymphocyte Count
- Male