Article
T-cell expansions with conserved T-cell receptor beta chain motifs in the peripheral blood of HLA-DRB1*0401 positive patients with necrotizing vasculitis.
Blood - 15 Nov 1998
Grunewald J, Halapi E, Wahlström J, Giscombe R, Nityanand S, Sanjeevi C, Lefvert A K
Abstract excerpt
T lymphocytes are implicated in the pathogenesis of systemic vasculitis such as Wegener's granulomatosis (WG) and polyarteritis nodosa (PAN). In the present study, we have characterized in detail the T-cell receptor (TCR) of peripheral blood T cells from eight vasculitis patients of known HLA class II genotypes. We used flow cytometry to outline the exact TCR V gene expression, complementarity determining region...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.