Article
Evolution and selection of primate T cell antigen receptor BV8 gene subfamily.
Molecular phylogenetics and evolution - 1 Aug 1997
Funkhouser W, Koop B F, Charmley P, Martindale D, Slightom J, Hood L
Abstract excerpt
The set of potential T cell receptor specificities is highly diverse. The relative contributions of T cell receptor (TCR) V beta gene segment polymorphisms, duplications, deletions, and gene conversions to this final T cell receptor protein diversity are unknown. To study these mechanisms, we seq...
Topics
- Adult
- Animals
- Base Sequence
- Evolution, Molecular
- Gene Rearrangement
- Genetic Variation
- Germ Cells
- Humans
- Molecular Sequence Data
- Multigene Family
- Phylogeny
- Polymorphism, Genetic
- Primates
- Receptors, Antigen, T-Cell, alpha-beta
- Restriction Mapping
- Selection, Genetic
- Sequence Alignment