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Article

Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.

The Journal of experimental medicine - 7 Mar 2016

Nuvolone Mario, Hermann Mario, Sorce Silvia, Russo Giancarlo, Tiberi Cinzia, Schwarz Petra, Minikel Eric, Sanoudou Despina, Pelczar Pawel, Aguzzi Adriano

Abstract excerpt

Although its involvement in prion replication and neurotoxicity during transmissible spongiform encephalopathies is undisputed, the physiological role of the cellular prion protein (PrP(C)) remains enigmatic. A plethora of functions have been ascribed to PrP(C) based on phenotypes of Prnp(-/-) mice. However, all currently available Prnp(-/-) lines were generated in embryonic stem cells from the 129 strain of the...

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Identifiers

PMID: 26926995
DOI: 10.1084/jem.20151610
PMCID: PMC4813672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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