Article
Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice.
Hepatology (Baltimore, Md.) - 1 Feb 1998
Ghebranious N, Sell S
Abstract excerpt
The major risk factors for human liver cancer: hepatitis B virus (HBV) related liver injury, male gender, aflatoxin exposure, and p53 expression, are evaluated and compared in experimental transgenic mouse models. Transgenic mice that express hepatitis B surface antigen (HBsAg) in their liver and...
Topics
- Aflatoxins
- Animals
- Carcinoma, Hepatocellular
- Chromosome Deletion
- Disease Models, Animal
- Female
- Genes, p53
- Hepatitis B
- Hepatitis B Surface Antigens
- Heterozygote
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Polymorphism, Single-Stranded Conformational
- Risk Factors