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Article

Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury.

PloS one - 1 Jan 2011

Na Bing, Huang Zhiming, Wang Qian, Qi Zhongxia, Tian Yongjun, Lu Cheng-Chan, Yu Jingwei, Hanes Martha A, Kakar Sanjay, Huang Eric J, Ou J-H James, Liu Limin, Yen T S Benedict

Abstract excerpt

Hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide, is most commonly caused by chronic hepatitis B virus (HBV) infection. However, whether HBV plays any direct role in carcinogenesis, other than indirectly causing chronic liver injury by inciting the host immune response, remains unclear. We have established two independent transgenic mouse lines expressing the complete genome of a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22022578
DOI: 10.1371/journal.pone.0026240
PMCID: PMC3192172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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