Article
Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury.
PloS one - 1 Jan 2011
Na Bing, Huang Zhiming, Wang Qian, Qi Zhongxia, Tian Yongjun, Lu Cheng-Chan, Yu Jingwei, Hanes Martha A, Kakar Sanjay, Huang Eric J, Ou J-H James, Liu Limin, Yen T S Benedict
Abstract excerpt
Hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide, is most commonly caused by chronic hepatitis B virus (HBV) infection. However, whether HBV plays any direct role in carcinogenesis, other than indirectly causing chronic liver injury by inciting the host immune re...
Topics
- Animals
- Carcinoma, Hepatocellular
- Chronic Disease
- Cyclin D1
- Hepatitis B virus
- Liver
- Liver Neoplasms, Experimental
- Male
- Mice
- Mice, Transgenic
- Mutagenesis, Insertional
- Mutation
- Unfolded Protein Response
- Virus Replication