The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice.

doi:10.1002/hep.510270411

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Article

The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice.

Hepatology (Baltimore, Md.) - 1 Apr 1998

Ghebranious N, Sell S

Abstract excerpt

The relative contribution to development of hepatocellular carcinoma of the mouse equivalent to the human p53ser249 mutation, found in human hepatocellular carcinoma associated with aflatoxin (AFB1) exposure, is compared with other major risk factors in a transgenic mouse model. Transgenic p53ser...

Topics

Aflatoxin B1
Animals
Carcinogens
Female
Genes, p53
Humans
Liver Neoplasms, Experimental
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Tumor Suppressor Protein p53

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