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Article

Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver Cancer

1 Jan 2005

Abstract excerpt

Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we have generated c-myc and c-myc/ TGF-alpha transgenic mice that are prone to liver cancer. These...

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PMID: 15805070
DOI: 10.1080/01926230590522095

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