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Article

Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region.

World journal of gastroenterology - 14 Mar 2018

Lee Seoung-Ae, Lee So-Young, Choi Yu-Min, Kim Hong, Kim Bum-Joon

Abstract excerpt

AIM: To study sex disparity in susceptibility to hepatocellular carcinoma (HCC), we created a transgenic mouse model that expressed the full hepatitis B virus (HBV) genome with the W4P mutation. METHODS: Transgenic mice were generated by transferring the pHY92-1.1x-HBV-full genome plasmid (genotype A2) into C57Bl/6N mice. We compared serum levels of hepatitis B surface antigen (HBsAg), interleukin (IL)-6, and the...

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Identifiers

PMID: 29563753
DOI: 10.3748/wjg.v24.i10.1084
PMCID: PMC5850128

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