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Article

The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation.

DNA repair - 1 Jul 2015

Sizova Daria V, Keh Agnes, Taylor Ben F, Sweasy Joann B

Abstract excerpt

X-ray repair cross complementing protein 1 (XRCC1) plays an important role in base excision DNA repair (BER) as a scaffolding protein for BER enzymes. BER is one of the basic DNA repair pathways repairing greater than 20,000 endogenous lesions per cell per day. Proper functioning of XRCC1, one of the most important players in BER, was suggested to be indispensable for effective DNA repair. Despite accumulating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26011397
DOI: 10.1016/j.dnarep.2015.05.005
PMCID: PMC4458331

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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