Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

XRCC1 is required for DNA single-strand break repair in human cells

28 Apr 2005

Abstract excerpt

The X-ray repair cross complementing 1 (XRCC1) protein is required for viability and efficient repair of DNA single-strand breaks (SSBs) in rodents. XRCC1-deficient mouse or hamster cells are hypersensitive to DNA damaging agents generating SSBs and display genetic instability after such DNA damage. The presence of certain polymorphisms in the human XRCC1 gene has been associated with altered cancer risk, but the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15867196
DOI: 10.1093/nar/gki543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

XRCC1 is required for DNA single-strand break repair in human cellsPMID 15867196Read ↗

XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells.Semantic proximity Read ↗

Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair.Semantic proximity Read ↗

XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair.Semantic proximity Read ↗

Mouse models of XRCC1 DNA repair polymorphisms and cancer.Semantic proximity Read ↗

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.Semantic proximity Read ↗

X-Ray Repair Cross Complementing Protein 1 in Base Excision RepairSemantic proximity Read ↗

DNA damage levels and biochemical repair capacities associated with XRCC1 deficiency.Semantic proximity Read ↗

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repairSemantic proximity Read ↗

Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regionsSemantic proximity Read ↗

Human Rad51C Deficiency Destabilizes XRCC3, Impairs Recombination, and Radiosensitizes S/G2-phase CellsSemantic proximity Read ↗

Role of the oxidized form of XRCC1 in protection against extreme oxidative stress.Semantic proximity Read ↗

The Role of the Human Psoralen 4 (hPso4) Protein Complex in Replication Stress and Homologous RecombinationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.