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Article

Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer.

Breast cancer research and treatment - 1 Jan 2005

Chacko Priya, Rajan Balakrishnan, Joseph Thomas, Mathew Beela Sarah, Pillai M Radhakrishna

Abstract excerpt

X-ray repair cross-complementing 1 (XRCC1) gene encodes for a scaffolding protein, which plays an important role in base excision DNA repair by bringing together DNA polymerase beta, DNA ligase III and poly(ADP-Ribose) polymerase (PARP) at the site of DNA damage. Three polymorphisms of the XRCC1 gene at codons 194, 280 and 399 leading to amino acid changes at evolutionary conserved regions are found to alter the...

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Source

Identifiers

PMID: 15666192
DOI: 10.1007/s10549-004-1004-x

Genes

XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to breast cancer.PMID 15666192Read ↗

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XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies.Semantic proximity Read ↗

A prospective study of XRCC1 (X-ray cross-complementing group 1) polymorphisms and breast cancer risk.Semantic proximity Read ↗

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