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Article

XRCC1 and DNA polymerase beta interaction contributes to cellular alkylating-agent resistance and single-strand break repair.

Journal of cellular biochemistry - 1 Jul 2005

Wong Heng-Kuan, Wilson David M

Abstract excerpt

X-ray cross complementing 1 (XRCC1) protein has been suggested to bind to DNA single-strand breaks (SSBs) and organize protein interactions that facilitate efficient DNA repair. Using four site-specifically modified human XRCC1 mutant expression systems and functional complementation assays in Chinese hamster ovary (CHO) XRCC1-deficient EM9 cells, we evaluated the cellular contributions of XRCC1s proposed...

Read the complete abstract on PubMed

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Share to Alkylating Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase beta

Share to DNA, Single-Stranded

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Source

Identifiers

PMID: 15838887
DOI: 10.1002/jcb.20448

Genes

XRCC1
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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