Article
Newly identified CHO ERCC3/XPB mutations and phenotype characterization.
Mutagenesis - 1 Mar 2010
Rybanská Ivana, Gursky Ján, Fasková Miriam, Salazar Edmund P, Kimlícková-Polakovicová Erika, Kleibl Karol, Thompson Larry H, Pirsel Miroslav
Abstract excerpt
Nucleotide excision repair (NER) is a complex multistage process involving many interacting gene products to repair a wide range of DNA lesions. Genetic defects in NER cause human hereditary diseases including xeroderma pigmentosum (XP), Cockayne syndrome (CS), trichothiodystrophy and a combined XP/CS overlapping symptom. One key gene product associated with all these disorders is the excision repair...
Topics
- Animals
- CHO Cells
- Cell Survival
- Comet Assay
- Cricetinae
- Cricetulus
- DNA Damage
- DNA Helicases
- DNA-Binding Proteins
- DNA-Formamidopyrimidine Glycosylase
- Mutation