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Article

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.

Nature - 29 Jan 1998

Jiang J, Struhl G

Abstract excerpt

Members of the Hedgehog (Hh) and Wnt/Wingless (Wg) families of secreted proteins control many aspects of growth and patterning during animal development. Hh signal transduction leads to increased stability of a transcription factor, Cubitus interruptus (Ci), whereas Wg signal transduction causes increased stability of Armadillo (Arm/beta-catenin), a possible co-factor for the transcriptional regulator Lef1/TCF....

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Identifiers

PMID: 9461217
DOI: 10.1038/35154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.PMID 9461217Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.Semantic proximity Read ↗

Transcriptional regulation of the Hedgehog effector CI by the zinc-finger gene combgap.Semantic proximity Read ↗

Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase.Semantic proximity Read ↗

The combgap locus encodes a zinc-finger protein that regulates cubitus interruptus during limb development in Drosophila melanogaster.Semantic proximity Read ↗

Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila.Semantic proximity Read ↗

A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.Semantic proximity Read ↗

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.Semantic proximity Read ↗

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.Semantic proximity Read ↗

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.Semantic proximity Read ↗

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