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Article

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.

Development (Cambridge, England) - 1 May 2006

Kent David, Bush Erik W, Hooper Joan E

Abstract excerpt

The final step in Hedgehog (Hh) signal transduction is post-translational regulation of the transcription factor, Cubitus interruptus (Ci). Ci resides in the cytoplasm in a latent form, where Hh regulates its processing into a transcriptional repressor or its nuclear access as a transcriptional activator. Levels of latent Ci are controlled by degradation, with different pathways activated in response to different...

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PMID: 16651542
DOI: 10.1242/dev.02370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.PMID 16651542Read ↗

Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal.Semantic proximity Read ↗

Ci: a complex transducer of the hedgehog signal.Semantic proximity Read ↗

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.Semantic proximity Read ↗

Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.Semantic proximity Read ↗

Regulation of Hedgehog Signal Transduction by Ubiquitination and DeubiquitinationSemantic proximity Read ↗

The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms.Semantic proximity Read ↗

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb.Semantic proximity Read ↗

Genetic dissection of the Drosophila Cubitus interruptus signaling complex.Semantic proximity Read ↗

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.Semantic proximity Read ↗

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.Semantic proximity Read ↗

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.Semantic proximity Read ↗

A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci.Semantic proximity Read ↗

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