Article
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.
Nature genetics - 1 Sept 1999
Sidow A, Bulotsky M S, Kerrebrock A W, Birren B W, Altshuler D, Jaenisch R, Johnson K R, Lander E S
Abstract excerpt
Early outgrowth of the vertebrate embryonic limb requires signalling by the apical ectodermal ridge (AER) to the progress zone (PZ), which in response proliferates and lays down the pattern of the presumptive limb in a proximal to distal progression. Signals from the PZ maintain the AER until the anlagen for the distal phalanges have been formed. The semidominant mouse mutant dactylaplasia (Dac) disrupts the...
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