Article
Comparison of cellular characteristics between human hepatoma cell lines with wild-type p53 and those with mutant-type p53 gene.
Acta medica Okayama - 1 Dec 1997
Pu H, Tsuji T, Kondo A, Fushimi K, Ohashi R, Inoue Y, Mimura T, Hamazaki K, Miyazaki M, Namba M
Abstract excerpt
Characteristics of human hepatoma cell lines with the wild-type p53 were compared with those of human hepatoma cell lines with the mutant-type p53. The p21 protein located downstream of p53 was expressed in cell lines with the wild-type p53 but was not expressed in cell lines with the mutant-type p53. As to other tumor suppressor genes such as p16 and p27, there was no difference in their expression between both...
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