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Article

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1 Mar 1990

Abstract excerpt

There is little information regarding the molecular mechanisms of hepatocarcinogenesis. We studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular carcinoma (HCC)-derived cell lines; six of seven showed p53 abnormalities. By Southern blotting, the p53 gene was found to be partially deleted in Hep 3B and rearranged in SK-HEP-1 cells. Transcripts of the p53 gene were undetectable in...

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Identifiers

PMID: 2155427
DOI: 10.1073/pnas.87.5.1973

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Source receipt: pubmed, retrieved 7 Sept 2026.

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