Article
Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 1993
Puisieux A, Galvin K, Troalen F, Bressac B, Marcais C, Galun E, Ponchel F, Yakicier C, Ji J, Ozturk M
Abstract excerpt
We analyzed the status of retinoblastoma and p53 genes in 10 human hepatoma cell lines. Polyclonal anti-peptide antibodies generated against peptides homologous to COOH-terminal and leucine-zipper domains of the retinoblastoma protein allowed us to identify two cell lines (Hep 3B and FOCUS) with...
Topics
- Amino Acid Sequence
- Blotting, Northern
- Carcinoma, Hepatocellular
- Chromosomes, Human, Pair 17
- Gene Expression
- Genes, Retinoblastoma
- Genes, p53
- Humans
- Immunosorbent Techniques
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Retinoblastoma Protein