Article
The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells.
Hepatology (Baltimore, Md.) - 1 Mar 1999
Schleger C, Becker R, Oesch F, Steinberg P
Abstract excerpt
A particular point mutation of the tumor suppressor gene p53, namely a G-->T transversion at the third base of codon 249, is frequently detected in primary hepatocellular carcinomas from patients living in areas where the levels of dietary exposure to aflatoxin B1 and the rates of infection with the hepatitis B virus are very high. Very recently, a nontumorigenic liver epithelial cell line (HACL-1) with a finite...
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