Article
Improvement in the differentiated hepatic phenotype of immortalized human hepatocytes by adenovirus mediated p21 gene transfer.
ASAIO journal (American Society for Artificial Internal Organs : 1992) - 1 Jan 2000
Kobayashi Oya, Sakaguchi Masakiyo, Okitsu Teru, Totsugawa Toshinori, Maruyama Masanobu, Matsumura Tochihisa, Watanabe Takamasa, Noguchi Hirofumi, Kosaka Yoshikazu, Fujiwara Toshiyoshi, Tanaka Noriaki
Abstract excerpt
The p21 molecule, a potent cyclin dependent kinase inhibitor, regulates the transition from the G1 phase to the S phase of the cell cycle and is involved in terminal cellular differentiation. The overexpression of p21 has been shown to induce differentiation in various cell lines. We have made an effort to establish a reliable human hepatocyte cell line as a source of hepatic function in bioartificial liver (BAL)...
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