Article
Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line.
International journal of cancer - 1 Sept 2010
Jiang Weidong, Wang Xin Wei, Unger Tamar, Forgues Marshonna, Kim Jin Woo, Hussain S Perwez, Bowman Elise, Spillare Elisa A, Lipsky Michael M, Meck Jeanne M, Cavalli Luciane R, Haddad Bassem R, Harris Curtis C
Abstract excerpt
Hepatocellular carcinoma (HCC) is a common cancer, and hepatitis B virus (HBV) is a major etiological agent. Convincing epidemiological and experimental evidence also links HCC to aflatoxin, a naturally occurring mycotoxin that produces a signature p53-249(ser) mutation. Recently, we have reported that tumor-derived HBx variants encoded by HBV exhibited attenuated transactivation and proapoptotic functions but...
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