A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein inhibits the function of transcriptional enhancers located distal to the promoter with respect to the location of su(Hw)-binding sites (insulation). Mutations in the modifier of mdg4 [mod(mdg4)] interfere with insulation and enhance the effect of the su(Hw)-binding region inserted in the y2 mutation by inhibiting the function of regulatory elements located on both...

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