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Article

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.

Cell - 25 Aug 1995

Gerasimova T I, Gdula D A, Gerasimov D V, Simonova O, Corces V G

Abstract excerpt

The suppressor of Hairy wing (su(Hw)) protein inhibits the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw)-binding sites. This polarity is due to the ability of the su(Hw)-binding region to form a chromatin insulator. Mutations in modifier of mdg4 (mod(mdg4)) enhance the effect of su(Hw) by inhibiting the function of enhancers located on both sides...

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Identifiers

PMID: 7664338
DOI: 10.1016/0092-8674(95)90031-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.PMID 7664338Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.Semantic proximity Read ↗

Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila.Semantic proximity Read ↗

The gypsy insulator of Drosophila affects chromatin structure in a directional manner.Semantic proximity Read ↗

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