A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.

doi:10.1016/0092-8674(95)90031-4

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Article

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.

Cell - 25 Aug 1995

Gerasimova T I, Gdula D A, Gerasimov D V, Simonova O, Corces V G

Abstract excerpt

The suppressor of Hairy wing (su(Hw)) protein inhibits the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw)-binding sites. This polarity is due to the ability of the su(Hw)-binding region to form a chromatin insulator. Mutations in modifier of mdg4 (mod(mdg4)) enhance the effect of su(Hw) by inhibiting the function of enhancers located on both sides...

Topics

Alleles
Amino Acid Sequence
Animals
Chromatin
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Enhancer Elements, Genetic
Gene Expression Regulation
Genes, Insect
Genes, Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leucine Zippers

Molecular Sequence Data

Mutation

Nuclear Proteins

Phenotype

Repressor Proteins

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 7664338
DOI: 10.1016/0092-8674(95)90031-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7664338-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.PMID 7664338Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.Semantic proximity Read ↗

Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila.Semantic proximity Read ↗

The gypsy insulator of Drosophila affects chromatin structure in a directional manner.Semantic proximity Read ↗

[Genetic analysis of the interaction of mutations in two genes, controlling expression of MDG4].Semantic proximity Read ↗

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