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Article

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.

Proceedings of the National Academy of Sciences of the United States of America - 23 May 1995

Georgiev P G, Corces V G

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein exerts a polar effect on gene expression by repressing the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw) binding sequences. The directionality of this effect suggests that the su(Hw) protein specifically interferes with the basic mechanism of enhancer action. Moreover, mutations in modifier of mdg4...

Topics

Alleles
Animals
Binding Sites
Chromosome Mapping
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster
Enhancer Elements, Genetic
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Insect

Genotype

Leucine Zippers

Male

Mutation

Nuclear Proteins

Promoter Regions, Genetic

Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7761470
DOI: 10.1073/pnas.92.11.5184
PMCID: PMC41873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7761470-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.PMID 7761470Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.Semantic proximity Read ↗

[Genetic analysis of the interaction of mutations in two genes, controlling expression of MDG4].Semantic proximity Read ↗

The gypsy insulator of Drosophila affects chromatin structure in a directional manner.Semantic proximity Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.Semantic proximity Read ↗

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