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Article

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.

Genetica - 1 Mar 2003

Dorn Rainer, Krauss Veiko

Abstract excerpt

The modifier of mdg4 (mod(mdg4)) gene of Drosophila melanogaster has been identified in many different genetic assays. It has been independently identified through mutations isolated for their effects on position effect variegation (PEV), the properties of insulator sequences, correct pathfinding of growing nerve cells, meiotic pairing of chromosomes, or apoptosis. Molecular analysis of the mod(mdg4) locus...

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PMID: 12723696
DOI: 10.1023/a:1022983810016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.PMID 12723696Read ↗

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.Semantic proximity Read ↗

Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.Semantic proximity Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

Mod(mdg4) variants repress telomeric retrotransposon <i>HeT-A</i> by blocking subtelomeric enhancersSemantic proximity Read ↗

Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins.Semantic proximity Read ↗

Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.Semantic proximity Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

The gene mod(mdg4) affects synapse specificity and structure in Drosophila.Semantic proximity Read ↗

Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Semantic proximity Read ↗

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