Article
Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.
Genetics - 1 Jul 2005
Golovnin Anton, Melnick Elena, Mazur Alexander, Georgiev Pavel
Abstract excerpt
The insulator element from the gypsy transposon is a DNA sequence that blocks activation of a promoter by a transcriptional enhancer when placed between them. The insulator contains reiterated binding sites for the Suppressor of Hairy-wing [Su(Hw)] zinc-finger protein. A protein encoded by another gene, modifier of mdg4 [mod(mdg4)], is also required for the enhancer-blocking activity of the Su(Hw) insulator. Here...
Topics
- Animals
- Binding Sites
- Crosses, Genetic
- DNA Mutational Analysis
- DNA Primers
- DNA Transposable Elements
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Gene Transfer Techniques
- Phenotype
- Pigmentation
- Promoter Regions, Genetic