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Article

Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.

Genetics - 1 Feb 2005

Gabler Manuela, Volkmar Michael, Weinlich Susan, Herbst Andreas, Dobberthien Philine, Sklarss Stefanie, Fanti Laura, Pimpinelli Sergio, Kress Horst, Reuter Gunter, Dorn Rainer

Abstract excerpt

The modifier of mdg4, mod(mdg4), locus in Drosophila melanogaster represents a new type of complex gene in which functional diversity is resolved by mRNA trans-splicing. A protein family of >30 transcriptional regulators, which are supposed to be involved in higher-order chromatin structure, is encoded by both DNA strands of this locus. Mutations in mod(mdg4) have been identified independently in a number of...

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Identifiers

PMID: 15520256
DOI: 10.1534/genetics.103.020842
PMCID: PMC1449142

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Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis.PMID 15520256Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Mod(mdg4) variants repress telomeric retrotransposon <i>HeT-A</i> by blocking subtelomeric enhancersSemantic proximity Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the drosophila testis.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

Cell lineage-specific expression of modulo, a dose-dependent modifier of variegation in Drosophila.Semantic proximity Read ↗

Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene <i>deadhead</i> within a heterochromatin mini-domainSemantic proximity Read ↗

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.Semantic proximity Read ↗

Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary.Semantic proximity Read ↗

dMi-2, a hunchback-interacting protein that functions in polycomb repression.Semantic proximity Read ↗

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