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Article

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.

Genetics - 1 Jan 1997

Gdula D A, Corces V G

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein represses enhancer function in a unidirectional fashion: enhancers segregated from the promoter by the su(Hw) binding region are rendered inactive. whereas those in the same domain are unaffected. In the case of the gypsy-induced y2 allele, the repressive effect of su(Hw) is rendered bidirectional in mod(mdg4) mutant flies, and all enhancers of the affected gene...

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Identifiers

PMID: 9017397
DOI: 10.1093/genetics/145.1.153
PMCID: PMC1207773

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Related research

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Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.PMID 9017397Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.Semantic proximity Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

The gypsy insulator of Drosophila affects chromatin structure in a directional manner.Semantic proximity Read ↗

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