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Article

Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.

Genetics - 1 Jan 1997

Gdula D A, Corces V G

Abstract excerpt

The suppressor of Hairy-wing [su(Hw)] protein represses enhancer function in a unidirectional fashion: enhancers segregated from the promoter by the su(Hw) binding region are rendered inactive. whereas those in the same domain are unaffected. In the case of the gypsy-induced y2 allele, the repres...

Topics

Animals
Conserved Sequence
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Deletion
Gene Expression Regulation
Insect Hormones
Male
Mutation
Nuclear Proteins
Repressor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Suppression, Genetic

Transcription Factors

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Identifiers

PMID: 9017397
DOI: 10.1093/genetics/145.1.153
PMCID: PMC1207773

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9017397-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Characterization of functional domains of the su(Hw) protein that mediate the silencing effect of mod(mdg4) mutations.PMID 9017397Read ↗

A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation.Semantic proximity Read ↗

The su(Hw) protein bound to gypsy sequences in one chromosome can repress enhancer-promoter interactions in the paired gene located in the other homolog.Semantic proximity Read ↗

A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4)1u1 mutation on y2 expression in Drosophila melanogaster.Semantic proximity Read ↗

Drosophila Su(Hw) insulator can stimulate transcription of a weakened yellow promoter over a distance.Semantic proximity Read ↗

Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations.Semantic proximity Read ↗

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.Semantic proximity Read ↗

The DNA-binding and enhancer-blocking domains of the Drosophila suppressor of Hairy-wing protein.Semantic proximity Read ↗

Investigation of the properties of non-gypsy suppressor of hairy-wing-binding sites.Semantic proximity Read ↗

The Drosophila melanogaster suppressor of Hairy-wing zinc finger protein has minimal effects on gene expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

The modifier of mdg4 locus in Drosophila: functional complexity is resolved by trans splicing.Semantic proximity Read ↗

The gypsy insulator of Drosophila affects chromatin structure in a directional manner.Semantic proximity Read ↗

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