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Article

Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.

Journal of autoimmunity - 1 Jun 1996

Harfouch-Hammoud E, Timsit J, Boitard C, Bach J F, Caillat-Zucman S

Abstract excerpt

Certain DQ alpha/beta dimeric molecules have been shown to play a major role in determining susceptibility or resistance to IDDM. Whether or not predisposition associated with DR4 haplotypes is exclusively due to linkage to DQB1*0302 and DQA1*0301 alleles is still a controversial issue. A modifying effect of certain DRB1*04 subtypes on the susceptibility encoded by DQ alleles is possible, since not all...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8816979
DOI: 10.1006/jaut.1996.0056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.PMID 8816979Read ↗

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.Semantic proximity Read ↗

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus.Semantic proximity Read ↗

Insulin-dependent diabetes mellitus in non-DR3/non-DR4 subjects.Semantic proximity Read ↗

HLA-DQA1 and DQB1 allele and genotype contribution to IDDM susceptibility in an ethnically mixed population.Semantic proximity Read ↗

Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM).Semantic proximity Read ↗

HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study. The Belgian Diabetes Registry.Semantic proximity Read ↗

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population.Semantic proximity Read ↗

The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.Semantic proximity Read ↗

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.Semantic proximity Read ↗

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