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Article

HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.

Diabetes - 1 Jan 1997

Undlien D E, Friede T, Rammensee H G, Joner G, Dahl-Jørgensen K, Søvik O, Akselsen H E, Knutsen I, Rønningen K S, Thorsby E

Abstract excerpt

Recent studies have shown that the risk conferred by the high-risk DQA1*03-DQB1*0302 (DQ8) haplotype is modified by the DRB1*04 allele that is also carried by this haplotype. However, many of these studies suffer from lack of sufficient numbers of DQ-matched control subjects, which are necessary because there is a strong linkage disequilibrium between genes in the HLA complex. In the present study, using a large...

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Source

Identifiers

PMID: 8971095
DOI: 10.2337/diab.46.1.143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.PMID 8971095Read ↗

Contribution of DRB1*04 variants to predisposition to or protection from insulin dependent diabetes mellitus is independent of dq.Semantic proximity Read ↗

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry.Semantic proximity Read ↗

The effect of HLA-B allele on the IDDM risk defined by DRB1*04 subtypes and DQB1*0302.Semantic proximity Read ↗

HLA-DRB1*0403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype.Semantic proximity Read ↗

The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1.Semantic proximity Read ↗

CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families.Semantic proximity Read ↗

HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population.Semantic proximity Read ↗

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis.Semantic proximity Read ↗

Susceptibility to type 1 (insulin-dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4?Semantic proximity Read ↗

Molecular epidemiology of insulin-dependent diabetes mellitus: WHO DiaMond Project. WHO DiaMond Molecular Epidemiology Sub-Project Group.Semantic proximity Read ↗

Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.Semantic proximity Read ↗

Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes.Semantic proximity Read ↗

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