Article
HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection.
Diabetes - 1 Jan 1997
Undlien D E, Friede T, Rammensee H G, Joner G, Dahl-Jørgensen K, Søvik O, Akselsen H E, Knutsen I, Rønningen K S, Thorsby E
Abstract excerpt
Recent studies have shown that the risk conferred by the high-risk DQA1*03-DQB1*0302 (DQ8) haplotype is modified by the DRB1*04 allele that is also carried by this haplotype. However, many of these studies suffer from lack of sufficient numbers of DQ-matched control subjects, which are necessary because there is a strong linkage disequilibrium between genes in the HLA complex. In the present study, using a large...
Topics
- Adolescent
- Child
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DR Antigens
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Haplotypes