Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.

doi:10.1111/j.1399-0039.1991.tb01854.x

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Article

Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.

Tissue antigens - 1 Mar 1991

Rønningen K S, Spurkland A, Iwe T, Vartdal F, Thorsby E

Abstract excerpt

We have studied 87 unrelated Caucasian insulin-dependent diabetes mellitus (IDDM) patients and 181 healthy controls by oligotyping for 20 DRB1, eight DQA1 and 13 DQB1 alleles, and established their DR-DQ haplotypes and DQ genotypes. An increase of DRB1 alleles encoding DR4 was found among IDDM patients, but the distribution of DR4 subtypes did not differ among DR4-positive IDDM patients and controls. The...

Topics

Adolescent
Adult
Alleles
Child
Child, Preschool
Diabetes Mellitus, Type 1
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease
Genotype
HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DRB1 Chains

Haplotypes

Histocompatibility Antigens Class II

Humans

Infant

Source

Open in PubMed

Identifiers

PMID: 1908143
DOI: 10.1111/j.1399-0039.1991.tb01854.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1908143-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Distribution of HLA-DRB1, -DQA1 and -DQB1 alleles and DQA1-DQB1 genotypes among Norwegian patients with insulin-dependent diabetes mellitus.PMID 1908143Read ↗

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