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Article

Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes.

Diabetologia - 1 Mar 2025

Redondo Maria J, Cuthbertson David, Steck Andrea K, Herold Kevan C, Oram Richard, Atkinson Mark, Brusko Todd M, Parikh Hemang M, Krischer Jeffrey P, Onengut-Gumuscu Suna, Rich Stephen S, Sosenko Jay M

Abstract excerpt

AIMS/HYPOTHESIS: Many studies of type 1 diabetes pathogenesis focus on individuals with high-risk HLA haplotypes. We tested the hypothesis that, among islet autoantibody-positive individuals, lacking HLA-DRB1*04-DQA1*03-DQB1*0302 (HLA-DR4-DQ8) and/or HLA-DRB1*0301-DQA1*0501-DQB1*0201 (HLA-DR3-DQ2) is associated with phenotypic differences, compared with those who have these high-risk HLA haplotypes. METHODS: We...

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Identifiers

PMID: 39670998
DOI: 10.1007/s00125-024-06338-7
PMCID: PMC11832693

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