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Article

The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.

The Journal of biological chemistry - 2 Jul 2010

Claessen Jasper H L, Mueller Britta, Spooner Eric, Pivorunas Valerie L, Ploegh Hidde L

Abstract excerpt

Terminally misfolded proteins that accumulate in the endoplasmic reticulum (ER) are dislocated and targeted for ubiquitin-dependent destruction by the proteasome. UBC6e is a tail-anchored E2 ubiquitin-conjugating enzyme that is part of a dislocation complex nucleated by the ER-resident protein SEL1L. Little is known about the turnover of tail-anchored ER proteins. We constructed a set of UBC6e transmembrane...

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Identifiers

PMID: 20435896
DOI: 10.1074/jbc.M110.120766
PMCID: PMC2898349

Genes

AUP1
YOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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