Article
The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.
Molecular biology of the cell - 15 Jan 2015
Mehnert Martin, Sommermeyer Franziska, Berger Maren, Kumar Lakshmipathy Sathish, Gauss Robert, Aebi Markus, Jarosch Ernst, Sommer Thomas
Abstract excerpt
Misfolded proteins of the secretory pathway are extracted from the endoplasmic reticulum (ER), polyubiquitylated by a protein complex termed the Hmg-CoA reductase degradation ligase (HRD-ligase), and degraded by cytosolic 26S proteasomes. This process is termed ER-associated protein degradation (ERAD). We previously showed that the membrane protein Der1, which is a subunit of the HRD-ligase, is involved in the...
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