Article
A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation.
EMBO reports - 1 Jul 2004
Medicherla Balasubrahmanyam, Kostova Zlatka, Schaefer Antje, Wolf Dieter H
Abstract excerpt
We developed a growth test to screen for yeast mutants defective in endoplasmic reticulum (ER) quality control and associated protein degradation (ERAD) using the membrane protein CTL*, a chimeric derivative of the classical ER degradation substrate CPY*. In a genomic screen of approximately 5,000 viable yeast deletion mutants, we identified genes necessary for ER quality control and degradation. Among the new...
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