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Article

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Nature cell biology - 1 Jan 2001

Bays N W, Gardner R G, Seelig L P, Joazeiro C A, Hampton R Y

Abstract excerpt

In eukaryotes, endoplasmic reticulum-associated degradation (ERAD) functions in cellular quality control and regulation of normal ER-resident proteins. ERAD proceeds by the ubiquitin-proteasome pathway, in which the covalent attachment of ubiquitin to proteins targets them for proteasomal degrada...

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PMID: 11146622
DOI: 10.1038/35050524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11146622-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.PMID 11146622Read ↗

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.Semantic proximity Read ↗

Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase.Semantic proximity Read ↗

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane.Semantic proximity Read ↗

Functional integrity of the SEL1L-HRD1 complex is critical for ERAD and organismal viabilitySemantic proximity Read ↗

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.Semantic proximity Read ↗

Derlin-3 Is Required for Changes in ERAD Complex Formation under ER Stress.Semantic proximity Read ↗

Transcriptomic analysis of SEL1L and HRD1 knockout cell lines reveals multifaceted roles of SEL1L beyond the ER quality controlSemantic proximity Read ↗

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.Semantic proximity Read ↗

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.Semantic proximity Read ↗

Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.Semantic proximity Read ↗

Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins.Semantic proximity Read ↗

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron.Semantic proximity Read ↗

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