Article
Comparison of sib-pair and variance-components methods for genomic screening.
Genetic epidemiology - 1 Jan 1997
Pugh E W, Jaquish C E, Sorant A J, Doetsch J P, Bailey-Wilson J E, Wilson A F
Abstract excerpt
The statistical properties of sib-pair and variance-components linkage methods were compared using the nuclear family data from Problem 2. Overall, the power to detect linkage was not high for either method. The variance-components method had better power for detection of linkage, particularly when covariates were included in the model. Type I error rates were similar to nominal error rates for both methods.
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