Article
Family-based tests of association in the presence of linkage.
American journal of human genetics - 1 Dec 2000
Lake S L, Blacker D, Laird N M
Abstract excerpt
Linkage analysis may not provide the necessary resolution for identification of the genes underlying phenotypic variation. This is especially true for gene-mapping studies that focus on complex diseases that do not exhibit Mendelian inheritance patterns. One positional genomic strategy involves application of association methodology to areas of identified linkage. Detection of association in the presence of...
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