Article
Association analysis in a variance components framework.
Genetic epidemiology - 1 Jan 2001
Abecasis G R, Cardon L R, Cookson W O, Sham P C, Cherny S S
Abstract excerpt
Association analyses conducted in a variance components framework can include information from all available individuals but remain unbiased in the presence of familiality or linkage. Models that include both linkage and association parameters provide different estimates of the effect of a single locus and can be used to distinguish causal polymorphisms from other types of variation. We examine some of these...
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