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Article

Combined linkage and association sib-pair analysis for quantitative traits.

American journal of human genetics - 1 Jan 1999

Fulker D W, Cherny S S, Sham P C, Hewitt J K

Abstract excerpt

An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between-...

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Identifiers

PMID: 9915965
DOI: 10.1086/302193
PMCID: PMC1377724

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