Article
Inhibition of HIV-1 replication by a Tat transdominant negative mutant in human peripheral blood lymphocytes from healthy donors and HIV-1-infected patients.
Gene therapy - 1 Nov 1997
Rossi C, Balboni P G, Betti M, Marconi P C, Bozzini R, Grossi M P, Barbanti-Brodano G, Caputo A
Abstract excerpt
It was previously shown that a tat mutant (tat22) where cysteine 22 is substituted by glycine behaves as a transdominant negative mutant in Jurkat T cells lytically or latently infected by HIV-1. In this study we demonstrate that tat22 controls HIV-1 replication in primary cells. This effect was...
Topics
- Gene Products, tat
- Genetic Therapy
- HIV Infections
- HIV-1
- Humans
- Mutation
- T-Lymphocytes
- Virus Replication
- tat Gene Products, Human Immunodeficiency Virus