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Article

A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996

Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E

Abstract excerpt

Study of the mechanism of HIV-1 postintegration latency in the ACH2 cell line demonstrates that these cells failed to increase HIV-1 production following treatment with exogenous Tat. Reasoning that the defect in ACH2 cells involves the Tat response, we analyzed the sequence of tat cDNA and Tat responsive element (TAR) from the virus integrated in ACH2. Tat cDNA sequence is closely related to that of HIV LAI, and...

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Identifiers

PMID: 8692823
DOI: 10.1073/pnas.93.13.6377
PMCID: PMC39030

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TNF

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Source receipt: pubmed, retrieved 7 Sept 2026.

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