Article
A point mutation in the HIV-1 Tat responsive element is associated with postintegration latency.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996
Emiliani S, Van Lint C, Fischle W, Paras P, Ott M, Brady J, Verdin E
Abstract excerpt
Study of the mechanism of HIV-1 postintegration latency in the ACH2 cell line demonstrates that these cells failed to increase HIV-1 production following treatment with exogenous Tat. Reasoning that the defect in ACH2 cells involves the Tat response, we analyzed the sequence of tat cDNA and Tat r...
Topics
- Base Sequence
- DNA Primers
- Gene Products, tat
- HIV Long Terminal Repeat
- HIV-1
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Point Mutation
- Proviruses
- Transfection
- Virus Latency
- Virus Replication
- tat Gene Products, Human Immunodeficiency Virus