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Article

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein.

Journal of virology - 1 Apr 1990

Rice A P, Carlotti F

Abstract excerpt

The Tat transactivator protein of human immunodeficiency virus type 1 contains a highly conserved cysteine-rich region, containing seven cysteines from residues 22 through 37. To investigate the importance of noncysteine residues in this region of the Tat protein, we have carried out a mutational analysis, in most cases substituting a single alanine for the wild-type noncysteine residue. Alanine substitution of...

Topics

Amino Acid Sequence
Animals
Cell Line
Cysteine
Gene Products, tat
HIV-1
Humans
Molecular Sequence Data
Mutation
Trans-Activators
Transfection
tat Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 2181156
DOI: 10.1128/JVI.64.4.1864-1868.1990
PMCID: PMC249332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2181156-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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