Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein.

Journal of virology - 1 Apr 1990

Rice A P, Carlotti F

Abstract excerpt

The Tat transactivator protein of human immunodeficiency virus type 1 contains a highly conserved cysteine-rich region, containing seven cysteines from residues 22 through 37. To investigate the importance of noncysteine residues in this region of the Tat protein, we have carried out a mutational analysis, in most cases substituting a single alanine for the wild-type noncysteine residue. Alanine substitution of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Line
Share to Cysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Trans-Activators

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2181156
DOI: 10.1128/JVI.64.4.1864-1868.1990
PMCID: PMC249332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat protein.PMID 2181156Read ↗

Does the human immunodeficiency virus Tat trans-activator contain a discrete activation domain?Semantic proximity Read ↗

A naturally occurring substitution in human immunodeficiency virus Tat increases expression of the viral genome.Semantic proximity Read ↗

Human immunodeficiency virus type 2 (HIV-2) trans-activator (Tat): functional domains and the search for trans-dominant negative mutants.Semantic proximity Read ↗

Inhibition of HIV-1 replication and reactivation from latency by tat transdominant negative mutants in the cysteine rich region.Semantic proximity Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

The 57th amino acid conveys the differential subcellular localization of human immunodeficiency virus-1 Tat derived from subtype B and C.Semantic proximity Read ↗

Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat TransactivatorSemantic proximity Read ↗

The activation region of the Tat protein of human immunodeficiency virus type-1 functions in yeast.Semantic proximity Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase.Semantic proximity Read ↗

Construction and characterization of a potent HIV-2 Tat transdominant mutant protein.Semantic proximity Read ↗

Substitution of the unique cysteine residue of murine Hsp25 interferes with the protective activity of this stress protein through inhibition of dimer formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.